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This Cochrane review included 115 randomized controlled trials, 92 of which were performed in China, and involved 60,479 women who had engaged in a single act of unprotected intercourse.¹ Both one-time low-dose (less than 25 mg) and moderate-dose (25 to 50 mg) oral mifepristone were superior when compared with one-time oral levonorgestrel, 1.5 mg (RR for low-dose mifepristone = 0.72; 95% CI, 0.52 to 0.99; n = 8,752; RR for moderate-dose mifepristone = 0.61; 95% CI, 0.45 to 0.83; n = 6,052).

For example, if the chance of pregnancy following unprotected intercourse and subsequent treatment with oral levonorgestrel is 20 women per 1,000, the chance following treatment with low-dose mifepristone would be between 10 and 20 women per 1,000.

In a different cohort, if the chance of pregnancy following treatment with oral levonorgestrel is 35 women per 1,000, then the chance after taking moderate-dose mifepristone is between 16 and 29 women per 1,000. One study confirmed that oral levonorgestrel can be given as a single dose or as two doses 12 hours apart, but no difference in effectiven

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